Overview

Interactive Variant Analysis (IVA) is a web application for filtering, analysis and interpretation of population-scale genotype data. This interactive tool allows the identification of genes affected by deleterious variants that segregate along family pedigrees, case-control or sporadic samples.

IVA has been developed as part of the OpenCGA project, making it easy to work with clinical and variant information stored in a Catalog and Variant storage instance.

Main Features

• Authenticated and secure platform to query and visualise data

• Fully customizable platform and extensible though pluggings

• Multiple tools and analysis available:

  • Advanced variant filtering: filter your variants

  • Genome browser

  • Clinical analysis

  • Aggregation analysis

• Allow to load VCF files and samples together with clinical data

• High-performance and scalable VCF and gVCF indexing

• VCF normalization and variant annotation

• Clinical interpretation analysis of samples and families

Contact

• Ignacio Medina

⚠️ IVA is developed and maintained by the University of Cambridge and Genomics England. It is freely available at https://github.com/opencb/iv