Overview

The Interactive Variant Analyser (IVA) is the web user interface for OpenCGA that provides unprecedented features for real-time interaction with genomic data. It is suitable for any scale; from the detailed interpretation of a single genomic test through to assessing the genetic diversity of hundreds of thousands of aggregated genomes. It is not just for bioinformaticians; it provides simple and convenient access for biomedical researchers and clinical scientists as well.

Features

• Variant Browser: Efficiently browse annotated variants normalised across all samples loaded into a project. Filter variants by multiple criteria including genomic, genetic consequence, population frequency, clinical, phenotype, deleteriousness, and conservation.

• Case Interpreter: Perform clinical interpretation of cases; singletons, families, cancer from panels, exomes and whole genomes, and record your interpretation findings directly into OpenCGA.

• Variant Analysis: Access a variety of analysis and QC tools, run asynchronously, at sample, individual and population level.

• Alignment Browser: interactively and smoothly visualise the genomic alignments (BAM/CRAM) associated with your samples.

• Catalog Browser: browse the files, samples, individuals and families associated with your studies

Benefits

• Authenticated and secure platform to query and visualise data

• Highly customisable; extensible though plugins

IVA has been developed as part of the OpenCGA project, making it easy to work with clinical and variant information stored in a Catalog and Variant storage instance.

Rich Configuration 💡

Administrators can highly customise their IVA installation through a rich set of configuration options. You can easily customise the navigation bar, welcome page, filters and many other aspects of the interface.